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Similarities and differences in the nucleic acid chaperone activity of HIV-2 and HIV-1 nucleocapsid proteins in vitro

BACKGROUND: The nucleocapsid domain of Gag and mature nucleocapsid protein (NC) act as nucleic acid chaperones and facilitate folding of nucleic acids at critical steps of retroviral replication cycle. The basic N-terminus of HIV-1 NC protein was shown most important for the chaperone activity. The...

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Detalles Bibliográficos
Autores principales: Pachulska-Wieczorek, Katarzyna, Stefaniak, Agnieszka K, Purzycka, Katarzyna J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227088/
https://www.ncbi.nlm.nih.gov/pubmed/24992971
http://dx.doi.org/10.1186/1742-4690-11-54