Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis

INTRODUCTION: The crucial role of innate immunity in the pathogenesis of systemic sclerosis (SSc) is well established, and in the past few years the hypothesis that Toll-like receptor 4 (TLR4) activation induced by endogenous ligands is involved in fibrogenesis has been supported by several studies...

Descripción completa

Detalles Bibliográficos
Autores principales: Stifano, Giuseppina, Affandi, Alsya J, Mathes, Allison L, Rice, Lisa M, Nakerakanti, Sashidhar, Nazari, Banafsheh, Lee, Jungeun, Christmann, Romy B, Lafyatis, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227089/
https://www.ncbi.nlm.nih.gov/pubmed/24984848
http://dx.doi.org/10.1186/ar4598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227089/
https://www.ncbi.nlm.nih.gov/pubmed/24984848
http://dx.doi.org/10.1186/ar4598

Ejemplares similares