A CD4(+) T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function

BACKGROUND: CD4(+) T cells are critically important in HIV infection, being both the primary cells infected by HIV and likely playing a direct or indirect role in helping control virus replication. Key areas of interest in HIV vaccine research are mechanisms of viral escape from the immune response....

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Detalles Bibliográficos
Autores principales: Jacobs, Evan S, Persad, Desmond, Ran, Longsi, Danesh, Ali, Heitman, John W, Deng, Xutao, Cameron, Mark J, Kelvin, David J, Norris, Philip J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227135/
https://www.ncbi.nlm.nih.gov/pubmed/24996903
http://dx.doi.org/10.1186/1742-4690-11-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227135/
https://www.ncbi.nlm.nih.gov/pubmed/24996903
http://dx.doi.org/10.1186/1742-4690-11-57

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