A CD4(+) T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function

BACKGROUND: CD4(+) T cells are critically important in HIV infection, being both the primary cells infected by HIV and likely playing a direct or indirect role in helping control virus replication. Key areas of interest in HIV vaccine research are mechanisms of viral escape from the immune response....

Descripción completa

Detalles Bibliográficos
Autores principales: Jacobs, Evan S, Persad, Desmond, Ran, Longsi, Danesh, Ali, Heitman, John W, Deng, Xutao, Cameron, Mark J, Kelvin, David J, Norris, Philip J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227135/
https://www.ncbi.nlm.nih.gov/pubmed/24996903
http://dx.doi.org/10.1186/1742-4690-11-57

Ejemplares similares

Ejemplares similares