Squamosamide Derivative FLZ Protects Retinal Pigment Epithelium Cells from Oxidative Stress through Activation of Epidermal Growth Factor Receptor (EGFR)-AKT Signaling

Reactive oxygen species (ROS)-mediated retinal pigment epithelium (RPE) cell apoptosis is attributed to age-related macular degeneration (AMD) pathogenesis. FLZ, a novel synthetic squamosamide derivative from a Chinese herb, Annona glabra, has displayed significant cyto-protective activity. In the c...

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Detalles Bibliográficos
Autores principales: Cheng, Li-Bo, Chen, Chun-Ming, Zhong, Hong, Zhu, Li-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227245/
https://www.ncbi.nlm.nih.gov/pubmed/25329617
http://dx.doi.org/10.3390/ijms151018762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227245/
https://www.ncbi.nlm.nih.gov/pubmed/25329617
http://dx.doi.org/10.3390/ijms151018762

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