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Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic State in Skeletal Muscle Aging

[Image: see text] The molecular mechanisms underlying skeletal muscle aging and associated sarcopenia have been linked to an altered oxidative status of redox-sensitive proteins. Reactive oxygen and reactive nitrogen species (ROS/RNS) generated by contracting skeletal muscle are necessary for optima...

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Detalles Bibliográficos
Autores principales: McDonagh, Brian, Sakellariou, Giorgos K., Smith, Neil T., Brownridge, Philip, Jackson, Malcolm J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227305/
https://www.ncbi.nlm.nih.gov/pubmed/25181601
http://dx.doi.org/10.1021/pr5006394