Efficient and Stereocontrolled Synthesis of 1,2,4-Trioxolanes Useful for Ferrous Iron-Dependent Drug Delivery

[Image: see text] Ferrous iron-promoted reduction of a hindered peroxide bond underlies the antimalarial action of the 1,2,4-trioxane artemisinin and the 1,2,4-trioxolane arterolane. In appropriately designed systems, a 1,2,4-trioxolane ring can serve as a trigger to realize ferrous iron-dependent a...

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Detalles Bibliográficos
Autores principales: Fontaine, Shaun D., DiPasquale, Antonio G., Renslo, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227544/
https://www.ncbi.nlm.nih.gov/pubmed/25331549
http://dx.doi.org/10.1021/ol5028392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227544/
https://www.ncbi.nlm.nih.gov/pubmed/25331549
http://dx.doi.org/10.1021/ol5028392

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