One-Electron Oxidation of Gemcitabine and Analogs: Mechanism of Formation of C3′ and C2′ Sugar Radicals

[Image: see text] Gemcitabine is a modified cytidine analog having two fluorine atoms at the 2′-position of the ribose ring. It has been proposed that gemcitabine inhibits RNR activity by producing a C3′• intermediate via direct H3′-atom abstraction followed by loss of HF to yield a C2′• with 3′-ket...

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Detalles Bibliográficos
Autores principales: Adhikary, Amitava, Kumar, Anil, Rayala, Ramanjaneyulu, Hindi, Ragda M., Adhikary, Ananya, Wnuk, Stanislaw F., Sevilla, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227712/
https://www.ncbi.nlm.nih.gov/pubmed/25296262
http://dx.doi.org/10.1021/ja5083156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227712/
https://www.ncbi.nlm.nih.gov/pubmed/25296262
http://dx.doi.org/10.1021/ja5083156

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