A Genetically Encoded aza-Michael Acceptor for Covalent Cross-Linking of Protein–Receptor Complexes

[Image: see text] Selective covalent bond formation at a protein–protein interface potentially can be achieved by genetically introducing into a protein an appropriately “tuned” electrophilic unnatural amino acid that reacts with a native nucleophilic residue in its cognate receptor upon complex for...

Descripción completa

Detalles Bibliográficos
Autores principales: Furman, Jennifer L., Kang, Mingchao, Choi, Seihyun, Cao, Yu, Wold, Erik D., Sun, Sophie B., Smider, Vaughn V., Schultz, Peter G., Kim, Chan Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227728/
https://www.ncbi.nlm.nih.gov/pubmed/24846839
http://dx.doi.org/10.1021/ja502851h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227728/
https://www.ncbi.nlm.nih.gov/pubmed/24846839
http://dx.doi.org/10.1021/ja502851h

Ejemplares similares