Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass

Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the fidelity and lesion bypass capacity of DinB2. We report that DinB2 is an unfaithful DNA and RNA polymerase with a distinctive...

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Detalles Bibliográficos
Autores principales: Ordonez, Heather, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227753/
https://www.ncbi.nlm.nih.gov/pubmed/25352547
http://dx.doi.org/10.1093/nar/gku1027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227753/
https://www.ncbi.nlm.nih.gov/pubmed/25352547
http://dx.doi.org/10.1093/nar/gku1027

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