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A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P
Ribonuclease P (RNase P) is an essential endonuclease that catalyzes the 5′ end maturation of precursor tRNA (pre-tRNA). Bacterial RNase P is an attractive potential antibacterial target because it is essential for cell survival and has a distinct subunit composition compared to the eukaryal counter...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227764/ https://www.ncbi.nlm.nih.gov/pubmed/25249623 http://dx.doi.org/10.1093/nar/gku850 |