Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor

The interest in RNA modification enzymes surges due to their involvement in epigenetic phenomena. Here we present a particularly informative approach to investigate the interaction of dye-labeled RNA with modification enzymes. We investigated pseudouridine (Ψ) synthase TruB interacting with an alleg...

Descripción completa

Detalles Bibliográficos
Autores principales: Spenkuch, Felix, Hinze, Gerald, Kellner, Stefanie, Kreutz, Christoph, Micura, Ronald, Basché, Thomas, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227767/
https://www.ncbi.nlm.nih.gov/pubmed/25300485
http://dx.doi.org/10.1093/nar/gku908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227767/
https://www.ncbi.nlm.nih.gov/pubmed/25300485
http://dx.doi.org/10.1093/nar/gku908

Ejemplares similares