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Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor
The interest in RNA modification enzymes surges due to their involvement in epigenetic phenomena. Here we present a particularly informative approach to investigate the interaction of dye-labeled RNA with modification enzymes. We investigated pseudouridine (Ψ) synthase TruB interacting with an alleg...
Autores principales: | Spenkuch, Felix, Hinze, Gerald, Kellner, Stefanie, Kreutz, Christoph, Micura, Ronald, Basché, Thomas, Helm, Mark |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227767/ https://www.ncbi.nlm.nih.gov/pubmed/25300485 http://dx.doi.org/10.1093/nar/gku908 |
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