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Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor

The interest in RNA modification enzymes surges due to their involvement in epigenetic phenomena. Here we present a particularly informative approach to investigate the interaction of dye-labeled RNA with modification enzymes. We investigated pseudouridine (Ψ) synthase TruB interacting with an alleg...

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Detalles Bibliográficos
Autores principales:	Spenkuch, Felix, Hinze, Gerald, Kellner, Stefanie, Kreutz, Christoph, Micura, Ronald, Basché, Thomas, Helm, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227767/ https://www.ncbi.nlm.nih.gov/pubmed/25300485 http://dx.doi.org/10.1093/nar/gku908

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