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Search by proteins for their DNA target site: 2. The effect of DNA conformation on the dynamics of multidomain proteins
Multidomain transcription factors, which are especially abundant in eukaryotic genomes, are advantageous to accelerate the search kinetics for target site because they can follow the intersegment transfer via the monkey-bar mechanism in which the protein forms a bridged intermediate between two dist...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227779/ https://www.ncbi.nlm.nih.gov/pubmed/25324311 http://dx.doi.org/10.1093/nar/gku933 |