A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

The p53 transcription factor plays an important role in genome integrity. To perform this task, p53 regulates the transcription of genes promoting various cellular outcomes including cell cycle arrest, apoptosis or senescence. The precise regulation of this activity remains elusive as numerous mecha...

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Detalles Bibliográficos
Autores principales: Bethuyne, Jonas, De Gieter, Steven, Zwaenepoel, Olivier, Garcia-Pino, Abel, Durinck, Kaat, Verhelle, Adriaan, Hassanzadeh-Ghassabeh, Gholamreza, Speleman, Frank, Loris, Remy, Gettemans, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227789/
https://www.ncbi.nlm.nih.gov/pubmed/25324313
http://dx.doi.org/10.1093/nar/gku962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227789/
https://www.ncbi.nlm.nih.gov/pubmed/25324313
http://dx.doi.org/10.1093/nar/gku962

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