Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes

The synthesis of adequate amounts of ribosomes is an essential task for the cell. It is therefore not surprising that regulatory circuits exist to organize the synthesis of ribosomal components. It has been shown that defect in ribosome biogenesis (ribosomal stress) induces apoptosis or cell cycle a...

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Detalles Bibliográficos
Autores principales: Gismondi, Angelo, Caldarola, Sara, Lisi, Gaia, Juli, Giada, Chellini, Lidia, Iadevaia, Valentina, Proud, Christopher G., Loreni, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227798/
https://www.ncbi.nlm.nih.gov/pubmed/25332393
http://dx.doi.org/10.1093/nar/gku996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227798/
https://www.ncbi.nlm.nih.gov/pubmed/25332393
http://dx.doi.org/10.1093/nar/gku996

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