Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP) underlie multiple steps in the nucleotide addition cycle and diverse regulatory mechanisms. These mechanisms include nascent RNA hairpin-stabilized pausing, which inhibits TL folding into the trigger helices (...

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Detalles Bibliográficos
Autores principales: Windgassen, Tricia A., Mooney, Rachel Anne, Nayak, Dhananjaya, Palangat, Murali, Zhang, Jinwei, Landick, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227799/
https://www.ncbi.nlm.nih.gov/pubmed/25336618
http://dx.doi.org/10.1093/nar/gku997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227799/
https://www.ncbi.nlm.nih.gov/pubmed/25336618
http://dx.doi.org/10.1093/nar/gku997

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