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Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase
The conformational dynamics of the polymorphous trigger loop (TL) in RNA polymerase (RNAP) underlie multiple steps in the nucleotide addition cycle and diverse regulatory mechanisms. These mechanisms include nascent RNA hairpin-stabilized pausing, which inhibits TL folding into the trigger helices (...
Autores principales: | Windgassen, Tricia A., Mooney, Rachel Anne, Nayak, Dhananjaya, Palangat, Murali, Zhang, Jinwei, Landick, Robert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227799/ https://www.ncbi.nlm.nih.gov/pubmed/25336618 http://dx.doi.org/10.1093/nar/gku997 |
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