Cargando…

Enzyme Architecture: Deconstruction of the Enzyme-Activating Phosphodianion Interactions of Orotidine 5′-Monophosphate Decarboxylase

[Image: see text] The mechanism for activation of orotidine 5′-monophosphate decarboxylase (OMPDC) by interactions of side chains from Gln215 and Try217 at a gripper loop and R235, adjacent to this loop, with the phosphodianion of OMP was probed by determining the kinetic parameters k(cat) and K(m)...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldman, Lawrence M., Amyes, Tina L., Goryanova, Bogdana, Gerlt, John A., Richard, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227808/
https://www.ncbi.nlm.nih.gov/pubmed/24958125
http://dx.doi.org/10.1021/ja505037v