Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1

G protein-coupled receptors (GPCRs) are the major transducers of external stimuli and key therapeutic targets in many pathological conditions. When activated by different ligands, one receptor can elicit multiple signalling cascades that are mediated by G proteins or β-arrestin, a process defined as...

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Detalles Bibliográficos
Autores principales: Flores-Otero, Jacqueline, Ahn, Kwang H., Delgado-Peraza, Francheska, Mackie, Ken, Kendall, Debra A., Yudowski, Guillermo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227836/
https://www.ncbi.nlm.nih.gov/pubmed/25081814
http://dx.doi.org/10.1038/ncomms5589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227836/
https://www.ncbi.nlm.nih.gov/pubmed/25081814
http://dx.doi.org/10.1038/ncomms5589

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