N-Terminal Cleavage and Release of the Ectodomain of Flt1 Is Mediated via ADAM10 and ADAM 17 and Regulated by VEGFR2 and the Flt1 Intracellular Domain

Flt is one of the cell surface VEGF receptors which can be cleaved to release an N-terminal extracellular fragment which, like alternately transcribed soluble Flt1 (sFlt1), can antagonize the effects of VEGF. In HUVEC and in HEK293 cells where Flt1 was expressed, metalloprotease inhibitors reduced F...

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Detalles Bibliográficos
Autores principales: Raikwar, Nandita S., Liu, Kang Z., Thomas, Christie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227870/
https://www.ncbi.nlm.nih.gov/pubmed/25387128
http://dx.doi.org/10.1371/journal.pone.0112794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227870/
https://www.ncbi.nlm.nih.gov/pubmed/25387128
http://dx.doi.org/10.1371/journal.pone.0112794

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