Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations

BACKGROUND: Artemisinin-based combinations currently recommended for treatment of uncomplicated Plasmodium falciparum malaria in many countries of sub-Saharan Africa are substrates of CYP enzymes. The cytochrome enzyme system is responsible for metabolism of about 80-90% of clinically used drugs. It...

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Detalles Bibliográficos
Autores principales: Marwa, Karol J, Schmidt, Theresa, Sjögren, Maria, Minzi, Omary MS, Kamugisha, Erasmus, Swedberg, Göte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228099/
https://www.ncbi.nlm.nih.gov/pubmed/25363545
http://dx.doi.org/10.1186/1475-2875-13-420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228099/
https://www.ncbi.nlm.nih.gov/pubmed/25363545
http://dx.doi.org/10.1186/1475-2875-13-420

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