Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans

Iron deficiency is the most common nutritional disorder worldwide with substantial impact on health and economy. Current treatments predominantly rely on soluble iron which adversely affects the gastrointestinal tract. We have developed organic acid-modified Fe(III) oxo-hydroxide nanomaterials, here...

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Autores principales: Pereira, Dora I.A., Bruggraber, Sylvaine F.A., Faria, Nuno, Poots, Lynsey K., Tagmount, Mani A., Aslam, Mohamad F., Frazer, David M., Vulpe, Chris D., Anderson, Gregory J., Powell, Jonathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228177/
https://www.ncbi.nlm.nih.gov/pubmed/24983890
http://dx.doi.org/10.1016/j.nano.2014.06.012
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author Pereira, Dora I.A.
Bruggraber, Sylvaine F.A.
Faria, Nuno
Poots, Lynsey K.
Tagmount, Mani A.
Aslam, Mohamad F.
Frazer, David M.
Vulpe, Chris D.
Anderson, Gregory J.
Powell, Jonathan J.
author_facet Pereira, Dora I.A.
Bruggraber, Sylvaine F.A.
Faria, Nuno
Poots, Lynsey K.
Tagmount, Mani A.
Aslam, Mohamad F.
Frazer, David M.
Vulpe, Chris D.
Anderson, Gregory J.
Powell, Jonathan J.
author_sort Pereira, Dora I.A.
collection PubMed
description Iron deficiency is the most common nutritional disorder worldwide with substantial impact on health and economy. Current treatments predominantly rely on soluble iron which adversely affects the gastrointestinal tract. We have developed organic acid-modified Fe(III) oxo-hydroxide nanomaterials, here termed nano Fe(III), as alternative safe iron delivery agents. Nano Fe(III) absorption in humans correlated with serum iron increase (P < 0.0001) and direct in vitro cellular uptake (P = 0.001), but not with gastric solubility. The most promising preparation (iron hydroxide adipate tartrate: IHAT) showed ~80% relative bioavailability to Fe(II) sulfate in humans and, in a rodent model, IHAT was equivalent to Fe(II) sulfate at repleting haemoglobin. Furthermore, IHAT did not accumulate in the intestinal mucosa and, unlike Fe(II) sulfate, promoted a beneficial microbiota. In cellular models, IHAT was 14-fold less toxic than Fe(II) sulfate/ascorbate. Nano Fe(III) manifests minimal acute intestinal toxicity in cellular and murine models and shows efficacy at treating iron deficiency anaemia. FROM THE CLINICAL EDITOR: This paper reports the development of novel nano-Fe(III) formulations, with the goal of achieving a magnitude less intestinal toxicity and excellent bioavailability in the treatment of iron deficiency anemia. Out of the tested preparations, iron hydroxide adipate tartrate met the above criteria, and may become an important tool in addressing this common condition.
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spelling pubmed-42281772014-11-13 Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans Pereira, Dora I.A. Bruggraber, Sylvaine F.A. Faria, Nuno Poots, Lynsey K. Tagmount, Mani A. Aslam, Mohamad F. Frazer, David M. Vulpe, Chris D. Anderson, Gregory J. Powell, Jonathan J. Nanomedicine Original Article Iron deficiency is the most common nutritional disorder worldwide with substantial impact on health and economy. Current treatments predominantly rely on soluble iron which adversely affects the gastrointestinal tract. We have developed organic acid-modified Fe(III) oxo-hydroxide nanomaterials, here termed nano Fe(III), as alternative safe iron delivery agents. Nano Fe(III) absorption in humans correlated with serum iron increase (P < 0.0001) and direct in vitro cellular uptake (P = 0.001), but not with gastric solubility. The most promising preparation (iron hydroxide adipate tartrate: IHAT) showed ~80% relative bioavailability to Fe(II) sulfate in humans and, in a rodent model, IHAT was equivalent to Fe(II) sulfate at repleting haemoglobin. Furthermore, IHAT did not accumulate in the intestinal mucosa and, unlike Fe(II) sulfate, promoted a beneficial microbiota. In cellular models, IHAT was 14-fold less toxic than Fe(II) sulfate/ascorbate. Nano Fe(III) manifests minimal acute intestinal toxicity in cellular and murine models and shows efficacy at treating iron deficiency anaemia. FROM THE CLINICAL EDITOR: This paper reports the development of novel nano-Fe(III) formulations, with the goal of achieving a magnitude less intestinal toxicity and excellent bioavailability in the treatment of iron deficiency anemia. Out of the tested preparations, iron hydroxide adipate tartrate met the above criteria, and may become an important tool in addressing this common condition. Elsevier 2014-11 /pmc/articles/PMC4228177/ /pubmed/24983890 http://dx.doi.org/10.1016/j.nano.2014.06.012 Text en Crown Copyright © Published by Elsevier Inc. All rights reserved. https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Original Article
Pereira, Dora I.A.
Bruggraber, Sylvaine F.A.
Faria, Nuno
Poots, Lynsey K.
Tagmount, Mani A.
Aslam, Mohamad F.
Frazer, David M.
Vulpe, Chris D.
Anderson, Gregory J.
Powell, Jonathan J.
Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
title Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
title_full Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
title_fullStr Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
title_full_unstemmed Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
title_short Nanoparticulate iron(III) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
title_sort nanoparticulate iron(iii) oxo-hydroxide delivers safe iron that is well absorbed and utilised in humans
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228177/
https://www.ncbi.nlm.nih.gov/pubmed/24983890
http://dx.doi.org/10.1016/j.nano.2014.06.012
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