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Functional conservation of HIV-1 Gag: implications for rational drug design

BACKGROUND: HIV-1 replication can be successfully blocked by targeting gag gene products, offering a promising strategy for new drug classes that complement current HIV-1 treatment options. However, naturally occurring polymorphisms at drug binding sites can severely compromise HIV-1 susceptibility...

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Detalles Bibliográficos
Autores principales: Li, Guangdi, Verheyen, Jens, Rhee, Soo-Yon, Voet, Arnout, Vandamme, Anne-Mieke, Theys, Kristof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228425/
https://www.ncbi.nlm.nih.gov/pubmed/24176092
http://dx.doi.org/10.1186/1742-4690-10-126