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The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration
Using mouse optic nerve (ON) crush as a CNS injury model, we and others have found that activation of the mammalian target of rapamycin complex 1 (mTORC1) in mature retinal ganglion cells by deletion of the negative regulators, phosphatase and tensin homolog (PTEN) and tuberous sclerosis 1, promotes...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228696/ https://www.ncbi.nlm.nih.gov/pubmed/25382660 http://dx.doi.org/10.1038/ncomms6416 |