Cargando…

Non-Invasive MRI and Spectroscopy of mdx Mice Reveal Temporal Changes in Dystrophic Muscle Imaging and in Energy Deficits

In Duchenne muscular dystrophy (DMD), a genetic disruption of dystrophin protein expression results in repeated muscle injury and chronic inflammation. Magnetic resonance imaging shows promise as a surrogate outcome measure in both DMD and rehabilitation medicine that is capable of predicting clinic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heier, Christopher R., Guerron, Alfredo D., Korotcov, Alexandru, Lin, Stephen, Gordish-Dressman, Heather, Fricke, Stanley, Sze, Raymond W., Hoffman, Eric P., Wang, Paul, Nagaraju, Kanneboyina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229202/ https://www.ncbi.nlm.nih.gov/pubmed/25390038 http://dx.doi.org/10.1371/journal.pone.0112477

Ejemplares similares

Glucocorticoid-Treated Mice Are an Inappropriate Positive Control for Long-Term Preclinical Studies in the mdx Mouse
por: Sali, Arpana, et al.
Publicado: (2012)

Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
por: Ziemba, Michael, et al.
Publicado: (2021)

The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice
por: Sali, Arpana, et al.
Publicado: (2013)

Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia
por: Duddy, William, et al.
Publicado: (2015)

Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse
por: Spurney, Christopher F., et al.
Publicado: (2010)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the mdx Mouse Model of Duchenne Muscular Dystrophy
por: Guerron, Alfredo D., et al.
Publicado: (2010)

Characterization of Dysferlin Deficient SJL/J Mice to Assess Preclinical Drug Efficacy: Fasudil Exacerbates Muscle Disease Phenotype
por: Rayavarapu, Sree, et al.
Publicado: (2010)

Behavioral and Locomotor Measurements Using an Open Field Activity Monitoring System for Skeletal Muscle Diseases
por: Tatem, Kathleen S., et al.
Publicado: (2014)

Decrease in Prosaposin in the Dystrophic mdx Mouse Brain
por: Gao, Hui-ling, et al.
Publicado: (2013)

Proteome Profiling of the Dystrophic mdx Mice Diaphragm
por: Mucha, Olga, et al.
Publicado: (2023)

Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy
por: Heier, Christopher R, et al.
Publicado: (2019)

Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice
por: Feder, David, et al.
Publicado: (2013)

Erythropoietin reduces the expression of myostatin in mdx dystrophic mice
por: Feder, D., et al.
Publicado: (2014)

Cardioprotective Effect of Whole Body Periodic Acceleration in Dystrophic Phenotype mdx Rodent
por: Uryash, Arkady, et al.
Publicado: (2021)

Mutation Types and Aging Differently Affect Revertant Fiber Expansion in Dystrophic Mdx and Mdx52 Mice
por: Echigoya, Yusuke, et al.
Publicado: (2013)

Dysfunctional Muscle and Liver Glycogen Metabolism in mdx Dystrophic Mice
por: Stapleton, David I., et al.
Publicado: (2014)

Dystrophic phenotype improvement in the diaphragm muscle of mdx mice by diacerhein
por: Mâncio, Rafael Dias, et al.
Publicado: (2017)

Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model
por: Jahnke, Vanessa E, et al.
Publicado: (2012)

Non-invasive Optical Imaging of Muscle Pathology in mdx Mice Using Cathepsin Caged Near-Infrared Imaging
por: Baudy, Andreas R., et al.
Publicado: (2010)

“Of Mice and Measures”: A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic: First Workshop Report: Examining current findings and opportunities around the emerging D2.B10-Dmd(mdx)/J (D2/mdx) model in context of the classic C57BL/10ScSn-Dmd(mdx)/J (Bl10/mdx)
por: Gordish-Dressman, Heather, et al.
Publicado: (2018)

Extensive but Coordinated Reorganization of the Membrane Skeleton in Myofibers of Dystrophic (mdx) Mice
por: Williams, McRae W., et al.
Publicado: (1999)

A proteasome inhibitor fails to attenuate dystrophic pathology in mdx mice
por: Selsby, Joshua, et al.
Publicado: (2012)

The FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx Mice
por: Wasala, Nalinda B., et al.
Publicado: (2015)

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice
por: Pelosi, Laura, et al.
Publicado: (2015)

Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle
por: Valentine, William J., et al.
Publicado: (2022)

Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice
por: Swiderski, Kristy, et al.
Publicado: (2021)

Effect of the IL-1 Receptor Antagonist Kineret(®) on Disease Phenotype in mdx Mice
por: Benny Klimek, Margaret E., et al.
Publicado: (2016)

Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin(-/-) Mice
por: Markham, Bruce E., et al.
Publicado: (2015)

Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes
por: Hoffman, Eric P., et al.
Publicado: (2018)

Dystrophic Changes in Extraocular Muscles after Gamma Irradiation in mdx:utrophin(+/−) Mice
por: McDonald, Abby A., et al.
Publicado: (2014)

Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle
por: Murphy, Sandra, et al.
Publicado: (2018)

Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice
por: Nogami, Ken'ichiro, et al.
Publicado: (2021)

Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice
por: Spurney, Christopher F, et al.
Publicado: (2011)

IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
por: Kostek, Matthew C, et al.
Publicado: (2012)

Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne
por: Thangarajh, Mathula, et al.
Publicado: (2019)

Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice
por: Swiderski, Kristy, et al.
Publicado: (2014)

MicroRNAs modulated by local mIGF-1 expression in mdx dystrophic mice
por: Pelosi, Laura, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_30lc94f2m1ltlmc762amolhk06