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Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

BACKGROUND: Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an important organ for extramedullary hematopoiesis and a common infiltration site in l...

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Detalles Bibliográficos
Autores principales: Ma, Shihui, Shi, Yingxu, Pang, Yakun, Dong, Fang, Cheng, Hui, Hao, Sha, Xu, Jing, Zhu, Xiaofan, Yuan, Weiping, Cheng, Tao, Zheng, Guoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229605/
https://www.ncbi.nlm.nih.gov/pubmed/25366136
http://dx.doi.org/10.1186/s13045-014-0071-7