Direct incorporation of the NKT-cell activator α-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy

BACKGROUND: Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer. In the current study, we analysed whether the natural killer T cell-activating glycolipid α-galactosylceramide could overcome immune suppression and improve vaccination aga...

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Detalles Bibliográficos
Autores principales: Singh, M, Quispe-Tintaya, W, Chandra, D, Jahangir, A, Venkataswamy, M M, Ng, T W, Sharma-Kharkwal, S, Carreño, L J, Porcelli, S A, Gravekamp, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229631/
https://www.ncbi.nlm.nih.gov/pubmed/25314062
http://dx.doi.org/10.1038/bjc.2014.486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229631/
https://www.ncbi.nlm.nih.gov/pubmed/25314062
http://dx.doi.org/10.1038/bjc.2014.486

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