Cargando…

Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours

BACKGROUND: In a clinical diagnostic laboratory, we evaluated the applicability of the Ion Proton sequencer for screening 409 cancer-related genes in solid tumours. METHODS: DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) tissue biopsy specimens of 55 solid tumours (20 with matched n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, R R, Patel, K P, Routbort, M J, Aldape, K, Lu, X, Manekia, J, Abraham, R, Reddy, N G, Barkoh, B A, Veliyathu, J, Medeiros, L J, Luthra, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229640/ https://www.ncbi.nlm.nih.gov/pubmed/25314059 http://dx.doi.org/10.1038/bjc.2014.518

Ejemplares similares

Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory
por: Mehrotra, Meenakshi, et al.
Publicado: (2017)

Genome-wide copy number aberrations and HER2 and FGFR1 alterations in primary breast cancer by molecular inversion probe microarray
por: Chen, Hui, et al.
Publicado: (2017)

Optimizing copy number variation analysis using genome-wide short sequence oligonucleotide arrays
por: Oldridge, Derek A., et al.
Publicado: (2010)

Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients
por: Wong, S Q, et al.
Publicado: (2015)

Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing
por: Wang, Bin, et al.
Publicado: (2010)

Human copy number variants are enriched in regions of low mappability
por: Monlong, Jean, et al.
Publicado: (2018)

The association between copy number aberration, DNA methylation and gene expression in tumor samples
por: Sun, Wei, et al.
Publicado: (2018)

Genome-Wide Massively Parallel Sequencing of Formaldehyde Fixed-Paraffin Embedded (FFPE) Tumor Tissues for Copy-Number- and Mutation-Analysis
por: Schweiger, Michal R., et al.
Publicado: (2009)

Copy number evolution with weighted aberrations in cancer
por: Zeira, Ron, et al.
Publicado: (2020)

Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants
por: Xi, Ruibin, et al.
Publicado: (2016)

Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing
por: Wederell, Elizabeth D., et al.
Publicado: (2008)

Integrated study of copy number states and genotype calls using high-density SNP arrays
por: Sun, Wei, et al.
Publicado: (2009)

DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas
por: Kamieniak, M M, et al.
Publicado: (2013)

Massively parallel sequencing of cell-free DNA in plasma for detecting gynaecological tumour-associated copy number alteration
por: Nakabayashi, Makoto, et al.
Publicado: (2018)

PTEN and PIK3CA gene copy numbers and poor outcomes in non-small cell lung cancer patients with gefitinib therapy
por: Fidler, M J, et al.
Publicado: (2011)

DNA copy number changes in young gastric cancer patients with special reference to chromosome 19
por: Varis, A, et al.
Publicado: (2003)

Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era
por: Montes-Moreno, Santiago, et al.
Publicado: (2018)

Alteration of the copy number and deletion of mitochondrial DNA in human hepatocellular carcinoma
por: Yin, P H, et al.
Publicado: (2004)

A Single Cell Level Based Method for Copy Number Variation Analysis by Low Coverage Massively Parallel Sequencing
por: Zhang, Chunlei, et al.
Publicado: (2013)

Massively parallel sequencing and genome-wide copy number analysis revealed a clonal relationship in benign metastasizing leiomyoma
por: Wu, Ren-Chin, et al.
Publicado: (2017)

The clinical significance of small copy number variants in neurodevelopmental disorders
por: Asadollahi, Reza, et al.
Publicado: (2014)

Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas
por: Martinez, V D, et al.
Publicado: (2010)

Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
por: Todd, Robert T, et al.
Publicado: (2020)

An integrated pipeline for next-generation sequencing and annotation of mitochondrial genomes
por: Jex, Aaron R., et al.
Publicado: (2010)

Publisher Correction: Massively parallel sequencing of cell-free DNA in plasma for detecting gynaecological tumour-associated copy number alteration
por: Nakabayashi, Makoto, et al.
Publicado: (2018)

Allele-specific copy number profiling by next-generation DNA sequencing
por: Chen, Hao, et al.
Publicado: (2015)

Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer
por: Zivanovic, Andrej, et al.
Publicado: (2023)

Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors
por: Mehrotra, Meenakshi, et al.
Publicado: (2017)

High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer
por: Kim, D-W, et al.
Publicado: (2008)

Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT
por: Brownhill, S C, et al.
Publicado: (2007)

Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component
por: Alonso, M Henar, et al.
Publicado: (2017)

Chromosomal Copy Number Variation in Saccharomyces pastorianus Is Evidence for Extensive Genome Dynamics in Industrial Lager Brewing Strains
por: van den Broek, M., et al.
Publicado: (2015)

Short somatic alterations at the site of copy number variation in breast cancer
por: Murakami, Fumi, et al.
Publicado: (2020)

Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning
por: May, Gemma E, et al.
Publicado: (2023)

Evidence for multi-copy Mega-NUMTs in the human genome
por: Lutz-Bonengel, Sabine, et al.
Publicado: (2021)

Copy number polymorphisms and anticancer pharmacogenomics
por: Gamazon, Eric R, et al.
Publicado: (2011)

Performance of a TthPrimPol-based whole genome amplification kit for copy number alteration detection using massively parallel sequencing
por: Deleye, Lieselot, et al.
Publicado: (2016)

Copy number variation in African Americans
por: McElroy, Joseph P, et al.
Publicado: (2009)

Event analysis using a massively parallel processor
por: Bale, A, et al.
Publicado: (1990)

Copy number variation in bipolar disorder
por: Green, E K, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0ueci91jvn7e82i6i0v1sqkcet