Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis

Disruption of polyubiquitin gene Ubb leads to early-onset reactive gliosis and adult-onset hypothalamic neurodegeneration in mice. However, it remains unknown why reduced levels of ubiquitin (Ub) due to loss of Ubb lead to these neural phenotypes. To determine whether or not the defects in neurons o...

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Detalles Bibliográficos
Autores principales: Ryu, Han-Wook, Park, Chul-Woo, Ryu, Kwon-Yul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229674/
https://www.ncbi.nlm.nih.gov/pubmed/25391618
http://dx.doi.org/10.1038/srep07026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229674/
https://www.ncbi.nlm.nih.gov/pubmed/25391618
http://dx.doi.org/10.1038/srep07026

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