Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells

BACKGROUND: Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations often have altered cell cycles that offer proliferative advantages and lead to the...

Descripción completa

Detalles Bibliográficos
Autores principales: Pappano, William N, Zhang, Qian, Tucker, Lora A, Tse, Chris, Wang, Jieyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229861/
https://www.ncbi.nlm.nih.gov/pubmed/24927813
http://dx.doi.org/10.1186/1471-2407-14-430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229861/
https://www.ncbi.nlm.nih.gov/pubmed/24927813
http://dx.doi.org/10.1186/1471-2407-14-430

Ejemplares similares