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Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells
BACKGROUND: Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations often have altered cell cycles that offer proliferative advantages and lead to the...
Autores principales: | Pappano, William N, Zhang, Qian, Tucker, Lora A, Tse, Chris, Wang, Jieyi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229861/ https://www.ncbi.nlm.nih.gov/pubmed/24927813 http://dx.doi.org/10.1186/1471-2407-14-430 |
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