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Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2
BACKGROUND: In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone formation. In this study, we used conditioned neuro...
Autores principales: | Liz, Márcia A, Mar, Fernando M, Santos, Telma E, Pimentel, Helena I, Marques, Ana M, Morgado, Marlene M, Vieira, Sílvia, Sousa, Vera F, Pemble, Hayley, Wittmann, Torsten, Sutherland, Calum, Woodgett, James R, Sousa, Mónica M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229956/ https://www.ncbi.nlm.nih.gov/pubmed/24923837 http://dx.doi.org/10.1186/1741-7007-12-47 |
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