SH2-Catalytic Domain Linker Heterogeneity Influences Allosteric Coupling across the SFK Family

[Image: see text] Src-family kinases (SFKs) make up a family of nine homologous multidomain tyrosine kinases whose misregulation is responsible for human disease (cancer, diabetes, inflammation, etc.). Despite overall sequence homology and identical domain architecture, differences in SH3 and SH2 re...

Descripción completa

Detalles Bibliográficos
Autores principales: Register, A. C., Leonard, Stephen E., Maly, Dustin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230323/
https://www.ncbi.nlm.nih.gov/pubmed/25302671
http://dx.doi.org/10.1021/bi5008194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230323/
https://www.ncbi.nlm.nih.gov/pubmed/25302671
http://dx.doi.org/10.1021/bi5008194

Ejemplares similares