Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies

INTRODUCTION: Activation of the mTOR pathway has been linked to the cytopathology and epileptogenicity of malformations, specifically Focal Cortical Dysplasia (FCD) and Tuberous Sclerosis (TSC). Experimental and clinical trials have shown than mTOR inhibitors have anti-epileptogenic effects in TS. D...

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Detalles Bibliográficos
Autores principales: Liu, Joan, Reeves, Cheryl, Michalak, Zuzanna, Coppola, Antonietta, Diehl, Beate, Sisodiya, Sanjay M, Thom, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230418/
https://www.ncbi.nlm.nih.gov/pubmed/25005575
http://dx.doi.org/10.1186/2051-5960-2-71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230418/
https://www.ncbi.nlm.nih.gov/pubmed/25005575
http://dx.doi.org/10.1186/2051-5960-2-71

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