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Modeling bioavailability to organs protected by biological barriers
Computational pharmacokinetic (PK) modeling gives access to drug concentration vs. time profiles in target organs and allows better interpretation of clinical observations of therapeutic or toxic effects. Physiologically-based PK (PBPK) models in particular, based on mechanistic descriptions of the...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230447/ https://www.ncbi.nlm.nih.gov/pubmed/25505653 http://dx.doi.org/10.1186/2193-9616-1-8 |