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Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin
Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the toxin uses as a trafficking receptor. Mn-induced GPP130 down-regulation, in addition to being a potential therapeutic approach against Shiga to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230593/ https://www.ncbi.nlm.nih.gov/pubmed/25079690 http://dx.doi.org/10.1091/mbc.E14-05-1003 |