Genetic Analysis of a Novel Tubulin Mutation That Redirects Synaptic Vesicle Targeting and Causes Neurite Degeneration in C. elegans

Neuronal cargos are differentially targeted to either axons or dendrites, and this polarized cargo targeting critically depends on the interaction between microtubules and molecular motors. From a forward mutagenesis screen, we identified a gain-of-function mutation in the C. elegans α-tubulin gene...

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Detalles Bibliográficos
Autores principales: Hsu, Jiun-Min, Chen, Chun-Hao, Chen, Yen-Chih, McDonald, Kent L., Gurling, Mark, Lee, Albert, Garriga, Gian, Pan, Chun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230729/
https://www.ncbi.nlm.nih.gov/pubmed/25392990
http://dx.doi.org/10.1371/journal.pgen.1004715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230729/
https://www.ncbi.nlm.nih.gov/pubmed/25392990
http://dx.doi.org/10.1371/journal.pgen.1004715

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