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FRET-FLIM Investigation of PSD95-NMDA Receptor Interaction in Dendritic Spines; Control by Calpain, CaMKII and Src Family Kinase

Little is known about the changes in protein interactions inside synapses during synaptic remodeling, as their live monitoring in spines has been limited. We used a FRET-FLIM approach in developing cultured rat hippocampal neurons expressing fluorescently tagged NMDA receptor (NMDAR) and PSD95, two...

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Detalles Bibliográficos
Autores principales: Doré, Kim, Labrecque, Simon, Tardif, Christian, De Koninck, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230936/
https://www.ncbi.nlm.nih.gov/pubmed/25393018
http://dx.doi.org/10.1371/journal.pone.0112170