Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects

Oxygen sensing by hypoxia-inducible factor prolyl hydroxylases (HIF-PHs) is the dominant regulatory mechanism of erythropoietin (EPO) expression. In chronic kidney disease (CKD), impaired EPO expression causes anemia, which can be treated by supplementation with recombinant human EPO (rhEPO). Howeve...

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Detalles Bibliográficos
Autores principales: Flamme, Ingo, Oehme, Felix, Ellinghaus, Peter, Jeske, Mario, Keldenich, Jörg, Thuss, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230943/
https://www.ncbi.nlm.nih.gov/pubmed/25392999
http://dx.doi.org/10.1371/journal.pone.0111838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230943/
https://www.ncbi.nlm.nih.gov/pubmed/25392999
http://dx.doi.org/10.1371/journal.pone.0111838

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