Molecular Dynamics Studies of the Inhibitor C34 Binding to the Wild-Type and Mutant HIV-1 gp41: Inhibitory and Drug Resistant Mechanism

Mutations on NHR (N-terminal heptad repeat) associated with resistance to fusion inhibitor were observed. In addition, mutations on CHR (C-terminal heptad repeat) accompanied NHR mutations of gp41 are noted in many cases, like N43D/S138A double mutation. In this work, we explored the drug resistant...

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Detalles Bibliográficos
Autores principales: Ma, Xueting, Tan, Jianjun, Su, Min, Li, Chunhua, Zhang, Xiaoyi, Wang, Cunxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230944/
https://www.ncbi.nlm.nih.gov/pubmed/25393106
http://dx.doi.org/10.1371/journal.pone.0111923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230944/
https://www.ncbi.nlm.nih.gov/pubmed/25393106
http://dx.doi.org/10.1371/journal.pone.0111923

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