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Redifferentiation of Adult Human β Cells Expanded In Vitro by Inhibition of the WNT Pathway
In vitro expansion of adult human islet β cells is an attractive solution for the shortage of tissue for cell replacement therapy of type 1 diabetes. Using a lineage tracing approach we have demonstrated that β-cell-derived (BCD) cells rapidly dedifferentiate in culture and can proliferate for up to...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231080/ https://www.ncbi.nlm.nih.gov/pubmed/25393025 http://dx.doi.org/10.1371/journal.pone.0112914 |