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Ca(2+)-Induced PRE-NMR Changes in the Troponin Complex Reveal the Possessive Nature of the Cardiac Isoform for Its Regulatory Switch
The interaction between myosin and actin in cardiac muscle, modulated by the calcium (Ca(2+)) sensor Troponin complex (Tn), is a complex process which is yet to be fully resolved at the molecular level. Our understanding of how the binding of Ca(2+) triggers conformational changes within Tn that are...
Autores principales: | Cordina, Nicole M., Liew, Chu K., Potluri, Phani R., Curmi, Paul M., Fajer, Piotr G., Logan, Timothy M., Mackay, Joel P., Brown, Louise J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231091/ https://www.ncbi.nlm.nih.gov/pubmed/25392916 http://dx.doi.org/10.1371/journal.pone.0112976 |
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