Atomistic Detailed Mechanism and Weak Cation-Conducting Activity of HIV-1 Vpu Revealed by Free Energy Calculations

The viral protein U (Vpu) encoded by HIV-1 has been shown to assist in the detachment of virion particles from infected cells. Vpu forms cation-specific ion channels in host cells, and has been proposed as a potential drug target. An understanding of the mechanism of ion transport through Vpu is des...

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Detalles Bibliográficos
Autores principales: Padhi, Siladitya, Burri, Raghunadha Reddy, Jameel, Shahid, Priyakumar, U. Deva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231112/
https://www.ncbi.nlm.nih.gov/pubmed/25392993
http://dx.doi.org/10.1371/journal.pone.0112983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231112/
https://www.ncbi.nlm.nih.gov/pubmed/25392993
http://dx.doi.org/10.1371/journal.pone.0112983

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