Effects of Tet-mediated Oxidation Products of 5-Methylcytosine on DNA Transcription in vitro and in Mammalian Cells

5-methylcytosine (5-mC) is a well-characterized epigenetic regulator in mammals. Recent studies showed that Ten-eleven translocation (Tet) proteins can catalyze the stepwise oxidation of 5-mC to produce 5-hydroxymethylcytosine (5-HmC), 5-formylcytosine (5-FoC) and 5-carboxylcytosine (5-CaC). The exc...

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Detalles Bibliográficos
Autores principales: You, Changjun, Ji, Debin, Dai, Xiaoxia, Wang, Yinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231326/
https://www.ncbi.nlm.nih.gov/pubmed/25394478
http://dx.doi.org/10.1038/srep07052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231326/
https://www.ncbi.nlm.nih.gov/pubmed/25394478
http://dx.doi.org/10.1038/srep07052

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