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Overexpression of heat shock transcription factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel

BACKGROUND: Heat Shock Transcription Factor 1 (HSF1) is activated under stress conditions. In turn, it induces expression of Heat Shock Proteins (HSPs), which are well-known regulators of protein homeostasis. Elevated levels of HSF1 and HSPs were observed in many types of tumors. The aim of the pres...

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Detalles Bibliográficos
Autores principales: Vydra, Natalia, Toma, Agnieszka, Glowala-Kosinska, Magdalena, Gogler-Piglowska, Agnieszka, Widlak, Wieslawa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231344/
https://www.ncbi.nlm.nih.gov/pubmed/24165036
http://dx.doi.org/10.1186/1471-2407-13-504