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TNF-α blockade is ineffective in animal models of established polycystic kidney disease
BACKGROUND: Given the large medical burden of polycystic kidney disease (PKD) and recent clinical trial failures, there is a need for novel, safe and effective treatments for the disorder. METHODS: In PCK rat and PKD2((ws25/w183)) mouse models, entanercept was administered once every three days at 5...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231369/ https://www.ncbi.nlm.nih.gov/pubmed/24160989 http://dx.doi.org/10.1186/1471-2369-14-233 |