α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein

Focal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults such as diabetes, HIV infection, and hypertension. Point mutations in theα-actinin-4 gene ACTN4 cause an autosomal dominant form of human FSGS. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, June, Le, Tu Cam, Kos, Claudine H, Henderson, Joel M, Allen, Phillip G, Denker, Bradley M, Pollak, Martin R
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423141/
https://www.ncbi.nlm.nih.gov/pubmed/15208719
http://dx.doi.org/10.1371/journal.pbio.0020167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423141/
https://www.ncbi.nlm.nih.gov/pubmed/15208719
http://dx.doi.org/10.1371/journal.pbio.0020167

Ejemplares similares