Cargando…

5-Hydroxytryptamine (5-HT) Cellular Sequestration during Chronic Exposure Delays 5-HT(3) Receptor Resensitization due to Its Subsequent Release

The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT(3)) receptors. We report that recombinantly expressed 5-HT(3)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hothersall, J. Daniel, Alexander, Amy, Samson, Andrew J., Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231679/ https://www.ncbi.nlm.nih.gov/pubmed/25281748 http://dx.doi.org/10.1074/jbc.M114.594796

Ejemplares similares

Mutagenic Analysis of the Intracellular Portals of the Human 5-HT(3)A Receptor
por: Carland, Jane E., et al.
Publicado: (2013)

Prolonged inhibition of 5-HT(3) receptors by palonosetron results from surface receptor inhibition rather than inducing receptor internalization
por: Hothersall, J Daniel, et al.
Publicado: (2013)

Potentiation of RSU-1069 tumour cytotoxicity by 5-hydroxytryptamine (5-HT).
por: Chaplin, D. J.
Publicado: (1986)

Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT(1) receptors
por: Edvinsson, Jacob C. A., et al.
Publicado: (2022)

Phylogenetic analyses of 5-hydroxytryptamine 3 (5-HT(3)) receptors in Metazoa
por: Rao, Santosh T. R. B., et al.
Publicado: (2023)

Oral morphine induces spinal 5‐hydroxytryptamine (5‐HT) release using an opioid receptor‐independent mechanism
por: Nakamura, Shingo, et al.
Publicado: (2023)

Possible Role of 5-Hydroxytryptamine (5-HT) Receptor on Human Sperm Motility Regulation
por: Omote, Maya, et al.
Publicado: (2023)

Stimulatory Effect of 5-Hydroxytryptamine (5-HT) on Rat Capsaicin-Sensitive Lung Vagal Sensory Neurons via Activation of 5-HT(3) Receptors
por: Hsu, Chun-Chun, et al.
Publicado: (2019)

High-affinity fluorescent ligands for the 5-HT(3) receptor
por: Simonin, Jonathan, et al.
Publicado: (2012)

RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT(3)A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits
por: Walstab, Jutta, et al.
Publicado: (2010)

5-Hydroxytryptamine (5-HT) Positively Regulates Pigmentation via Inducing Melanoblast Specification and Melanin Synthesis in Zebrafish Embryos
por: Liu, Li, et al.
Publicado: (2020)

Distribution of 5-HT(3), 5-HT(4), and 5-HT(7) Receptors Along the Human Colon
por: Yaakob, Nor S, et al.
Publicado: (2015)

Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor
por: Windisch, Dirk, et al.
Publicado: (2015)

Review: 5-HT(1), 5-HT(2), 5-HT(3) and 5-HT(7) Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
por: Cortes-Altamirano, Jose Luis, et al.
Publicado: (2018)

5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved
por: Davis, Robert Patrick, et al.
Publicado: (2012)

5-Hydroxytryptamine 6 Receptor (5-HT(6)R)-Mediated Morphological Changes via RhoA-Dependent Pathways
por: Rahman, Md. Ataur, et al.
Publicado: (2017)

Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease
por: Neumann, Joachim, et al.
Publicado: (2023)

Conservation of 5-HT(1A) receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
por: Araragi, Naozumi, et al.
Publicado: (2013)

Structural Determinants of Ca(2+) Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor
por: Livesey, Matthew R., et al.
Publicado: (2008)

Regulation of Oligomeric Organization of the Serotonin 5-Hydroxytryptamine 2C (5-HT(2C)) Receptor Observed by Spatial Intensity Distribution Analysis
por: Ward, Richard J., et al.
Publicado: (2015)

Human 5–HT(4) and 5–HT(7) Receptor Splice Variants: Are they Important?
por: Coupar, Ian M, et al.
Publicado: (2007)

Discriminating between 5-HT(3)A and 5-HT(3)AB receptors
por: Thompson, AJ, et al.
Publicado: (2013)

Control of Amygdala Circuits by 5-HT Neurons via 5-HT and Glutamate Cotransmission
por: Sengupta, Ayesha, et al.
Publicado: (2017)

5-HT(2A), 5-HT(1B/D), 5HT(3) and 5-HT(7) receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle
por: Da Costa Guevara, Darwin, et al.
Publicado: (2021)

5-HT1A agonists, 5-HT3 antagonists and benzodiazepines : their comparative behavioural pharmacology /
Publicado: (1991)

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT
por: Sia, Tiong C., et al.
Publicado: (2013)

Constitutively Active 5-HT Receptors: An Explanation of How 5-HT Antagonists Inhibit Gut Motility in Species Where 5-HT is Not an Enteric Neurotransmitter?
por: Spencer, Nick J.
Publicado: (2015)

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT(2A) and 5-HT(2B) receptors in chondrocytes
por: Hori, Ayaka, et al.
Publicado: (2017)

5- Hydroxytryptamine
por: Giarman, Nicholas J.
Publicado: (1958)

5-HT(3) Receptors
por: Lummis, Sarah C. R.
Publicado: (2012)

Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro
por: Gwynne, Rachel M., et al.
Publicado: (2014)

5-HT and Intraplatelet 5-HT: a potential upstream regulator of YAP in liver regeneration
por: He, Chao, et al.
Publicado: (2019)

Cellular mechanisms of the 5-HT(7) receptor-mediated signaling
por: Guseva, Daria, et al.
Publicado: (2014)

Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT(2)/5-HT(3)/5-HT(4) ligands
por: Bell, Rob, et al.
Publicado: (2014)

Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development
por: Nikolić, Jelena, et al.
Publicado: (2023)

Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives
por: DELGERMURUN, Dugar, et al.
Publicado: (2015)

Biophysical validation of serotonin 5-HT(2A) and 5-HT(2C) receptor interaction
por: Felsing, Daniel E., et al.
Publicado: (2018)

The role of 5-HT receptors in depression
por: Yohn, Christine N., et al.
Publicado: (2017)

5-HT Receptors and Temperature Homeostasis
por: Voronova, Irina P.
Publicado: (2021)

Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 Receptors in the Head Twitch Response Induced by 5-Hydroxytryptophan and Psilocybin: Translational Implications
por: Shahar, Orr, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m0gqfet9vkk247jjnfqua853m6