A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry

Binding to the primary receptor, CD4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer (gp120(3)/gp41(3)) of human immunodeficiency virus (HIV-1) that are important for virus entry into host cells. These changes include an “opening” of the trimer, creation of a bi...

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Detalles Bibliográficos
Autores principales: Herschhorn, Alon, Gu, Christopher, Espy, Nicole, Richard, Jonathan, Finzi, Andrés, Sodroski, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231716/
https://www.ncbi.nlm.nih.gov/pubmed/25174000
http://dx.doi.org/10.1038/nchembio.1623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231716/
https://www.ncbi.nlm.nih.gov/pubmed/25174000
http://dx.doi.org/10.1038/nchembio.1623

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